mir-181 microRNA precursor
miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species (MIPF0000007). It has been shown that miR-181 is preferentially expressed in the B-lymphoid cells of mouse bone marrow,[1] but also in the retina and brain.[2]
Targets of miR-181
- Naguibneva et al. showed that miR-181 targets the homeobox protein Hox-A11 and participates in establishing muscle tissue.[3]
- Pekarsky et al.. showed that the Tcl1 oncogene is a target of miR-181.[4]
- Kazenwadel et al. showed that miR-181a binds the 3' UTR of Prox1 leading to translation repression and transcript degradation. Prox1 is a homeobox transcription factor involved in development of the lymphatic endothelium.[5]
References
- ^ Chen CZ, Li L, Lodish HF, Bartel DP (2004). "MicroRNAs modulate hematopoietic lineage differentiation". Science 303 (5654): 83–6. doi:10.1126/science.1091903. PMID 14657504.
- ^ Ryan DG, Oliveira-Fernandes M, Lavker RM (2006). "MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity". Mol. Vis. 12: 1175–84. PMID 17102797.
- ^ Naguibneva I, Ameyar-Zazoua M, Polesskaya A, et al (2006). "The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation". Nat. Cell Biol. 8 (3): 278–84. doi:10.1038/ncb1373. PMID 16489342.
- ^ Pekarsky Y, Santanam U, Cimmino A, et al (2006). "Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181". Cancer Res. 66 (24): 11590–3. doi:10.1158/0008-5472.CAN-06-3613. PMID 17178851.
- ^ Kazenwadel J, Michael MZ, Harvey NL (June 2010). "Prox1 expression is negatively regulated by miR-181 in endothelial cells". Blood 116 (13): 2395–2401. doi:10.1182/blood-2009-12-256297. PMID 20558617.
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